Medical References

Chromium

Forte G, Bocca B, Peruzzu A, Tolu F, Asara Y, Farace C, Oggiano R, Madeddu R. Blood Metals Concentration in Type 1 and Type 2 Diabetics. Biol Trace Elem Res. 2013 Nov 14. [Epub ahead of print]

Abdollahi M, Farshchi A, Nikfar S, Seyedifar MEffect of chromium on glucose and lipid profiles in patients with type 2 diabetes; a meta-analysis review of randomized trials.J Pharm Pharm Sci. 2013;16(1):99-114.

Sahin K, Tuzcu M, Orhan C, Sahin N, Kucuk O, Ozercan IH, Juturu V, Komorowski JR.Anti-diabetic activity of chromium picolinate and biotin in rats with type 2 diabetes induced by high-fat diet and streptozotocin.Br J Nutr. 2013 Jul 28;110(2):197-205

Surani SR, Ratnani I, Guntupalli B, Bopparaju S.Severe insulin resistance treatment with intravenous chromium in septic shock patient.World J Diabetes. 2012 Sep 15;3(9):170-3

Karagun BS, Temiz F, Ozer G, Yuksel B, Topaloglu AK, Mungan NO, Mazman M, Karagun GM.Chromium levels in healthy and newly diagnosed type 1 diabetic children.Pediatr Int. 2012 Dec;54(6):780-5.

Komorowski JR, Tuzcu M, Sahin N, Juturu V, Orhan C, Ulas M, Sahin KChromium picolinate modulates serotonergic properties and carbohydrate metabolism in a rat model of diabetes.Biol Trace Elem Res. 2012 Oct;149(1):50-6.

Hua Y, Clark S, Ren J, Sreejayan N.Molecular mechanisms of chromium in alleviating insulin resistance.J Nutr Biochem. 2012 Apr;23(4):313-9.

Drake TC, Rudser KD, Seaquist ER, Saeed A.Chromium infusion in hospitalized patients with severe insulin resistance: a retrospective analysis.Endocr Pract. 2012 May-Jun;18(3):394-8.

Bahijri SM, Alissa EM.Increased insulin resistance is associated with increased urinary excretion of chromium in non-diabetic, normotensive Saudi adults.J Clin Biochem Nutr. 2011 Nov;49(3):164-8.

Sharma S, Agrawal RP, Choudhary M, Jain S, Goyal S, Agarwal V.Beneficial effect of chromium supplementation on glucose, HbA1C and lipid variables in individuals with newly onset type-2 diabetes.J Trace Elem Med Biol. 2011 Jul;25(3):149-53

Krikorian R, Eliassen JC, Boespflug EL, Nash TA, Shidler MDImproved cognitive-cerebral function in older adults with chromium supplementation.Nutr Neurosci. 2010 Jun;13(3):116-22.

Cefalu WT, Rood J, Pinsonat P, Qin J, Sereda O, Levitan L, Anderson RA, Zhang XH, Martin JM, Martin CK, Wang ZQ, Newcomer B.Characterization of the metabolic and physiologic response to chromium supplementation in subjects with type 2 diabetes mellitus.Metabolism. 2010 May;59(5):755-62

Lai MH.Antioxidant effects and insulin resistance improvement of chromium combined with vitamin C and e supplementation for type 2 diabetes mellitus.J Clin Biochem Nutr. 2008 Nov;43(3):191-8.

Anton SD, Morrison CD, Cefalu WT, Martin CK, Coulon S, Geiselman P, Han H, White CL, Williamson DA.Effects of chromium picolinate on food intake and satiety.Diabetes Technol Ther. 2008 Oct;10(5):405-12

Lau FC, Bagchi M, Sen CK, Bagchi D.Nutrigenomic basis of beneficial effects of chromium(III) on obesity and diabetes.Mol Cell Biochem. 2008 Oct;317(1-2):1-10.

Anderson RA.Chromium and polyphenols from cinnamon improve insulin sensitivity.Proc Nutr Soc. 2008 Feb;67(1):48-53

Hummel M, Standl E, Schnell O.Chromium in metabolic and cardiovascular disease.Horm Metab Res. 2007 Oct;39(10):743-51.

Albarracin C, Fuqua B, Geohas J, Juturu V, Finch MR, Komorowski JR.Combination of chromium and biotin improves coronary risk factors in hypercholesterolemic type 2 diabetes mellitus: a placebo-controlled, double-blind randomized clinical trial.J Cardiometab Syndr. 2007 Spring;2(2):91-7.

Albarracin CA, Fuqua BC, Evans JL, Goldfine ID.Chromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes.Diabetes Metab Res Rev. 2008 Jan-Feb;24(1):41-51.

Geohas J, Daly A, Juturu V, Finch M, Komorowski JR.Chromium picolinate and biotin combination reduces atherogenic index of plasma in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial.Am J Med Sci. 2007 Mar;333(3):145-53.

JULIE MARTIN, ZHONG Q. WANG, XIAN H. ZHANG, DEBORAHWACHTEL, JULIA VOLAUFOVA, DWIGHT E. MATTHEWS, WILLIAM T. CEFALU, Chromium Picolinate Supplementation Attenuates Body Weight Gain and Increases Insulin Sensitivity in Subjects With Type 2 Diabetes. Diabetes Care 29:1826–1832, 2006

Broadhurst CL, Domenico P.Clinical studies on chromium picolinate supplementation in diabetes mellitus–a review.Diabetes Technol Ther. 2006 Dec;8(6):677-87.

Singer GM, Geohas J.The effect of chromium picolinate and biotin supplementation on glycemic control in poorly controlled patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized trial.Diabetes Technol Ther. 2006 Dec;8(6):636-43.

Martin J, Wang ZQ, Zhang XH, Wachtel D, Volaufova J, Matthews DE, Cefalu WT.Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes.Diabetes Care. 2006 Aug;29(8):1826-32.

Vladeva SV, Terzieva DD, Arabadjiiska DT.Effect of chromium on the insulin resistance in patients with type II diabetes mellitus.Folia Med (Plovdiv). 2005;47(3-4):59-62.

Docherty JP, Sack DA, Roffman M, Finch M, Komorowski JR.A double-blind, placebo-controlled, exploratory trial of chromium picolinate in atypical depression: effect on carbohydrate craving.J Psychiatr Pract. 2005 Sep;11(5):302-14.

Fuhr JP Jr, He H, Goldfarb N, Nash DB.Use of chromium picolinate and biotin in the management of type 2 diabetes: an economic analysis.Dis Manag. 2005 Aug;8(4):265-75.

Rabinovitz H, Friedensohn A, Leibovitz A, Gabay G, Rocas C, Habot BEffect of chromium supplementation on blood glucose and lipid levels in type 2 diabetes mellitus elderly patients.Int J Vitam Nutr Res. 2004 May;74(3):178-82.

Ghosh D, Bhattacharya B, Mukherjee B, Manna B, Sinha M, Chowdhury J, Chowdhury S.Role of chromium supplementation in Indians with type 2 diabetes mellitus.J Nutr Biochem. 2002 Nov;13(11):690-697.

Anderson RA, Cheng N, Bryden NA, Polansky MM, Cheng N, Chi J, Feng J.Elevated intakes of supplemental chromium improve glucose and insulin variables in individuals with type 2 diabetes.Diabetes. 1997 Nov;46(11):1786-91.

Alpha Lipoic Acid

Hegazy SK, Tolba OA, Mostafa TM, Eid MA, El-Afify DR.Alpha-lipoic Acid improves subclinical left ventricular dysfunction in asymptomatic patients with type 1 diabetes. Rev Diabet Stud. 2013 Spring;10(1):58-67.

Udupa A, Nahar P, Shah S, Kshirsagar M, Ghongane B.A comparative study of effects of omega-3 Fatty acids, alpha lipoic Acid and vitamin e in type 2 diabetes mellitus.Ann Med Health Sci Res. 2013 Jul;3(3):442-6

Cappelli V, Di Sabatino A, Musacchio MC, De Leo V.Evaluation of a new association between insulin-sensitizers and α-lipoic acid in obese women affected by PCOS.

Sezione di Ostetricia e Ginecologia, Dipartimento di Medicina Molecolare e dello Sviluppo, Universitàdegli Studi di Siena Siena, Italia

Mitkov MD, Aleksandrova IY, Orbetzova MM.Effect of transdermal testosterone or alpha-lipoic acid on erectile dysfunction and quality of life in patients with type 2 diabetes mellitus. Folia Med (Plovdiv). 2013 Jan-Mar;55(1):55-63.

Nebbioso M, Pranno F, Pescosolido NLipoic acid in animal models and clinical use in diabetic retinopathy.Opin Pharmacother. 2013 Sep;14(13):1829-38. doi: 10.1517/14656566.2013.813483. Epub 2013 Jun 22.

Ibrahimpasic K.Alpha lipoic acid and glycaemic control in diabetic neuropathies at type 2 diabetes treatment.Med Arh. 2013;67(1):7-9.

Rochette L, Ghibu S, Richard C, Zeller M, Cottin Y, Vergely C.Direct and indirect antioxidant properties of α-lipoic acid and therapeutic potential. Mol Nutr Food Res. 2013 Jan;57(1):114-25.

Udupa AS, Nahar PS, Shah SH, Kshirsagar MJ, Ghongane BB.Study of comparative effects of antioxidants on insulin sensitivity in type 2 diabetes mellitus. J Clin Diagn Res. 2012 Nov;6(9):1469-73.

Castro MC, Massa ML, Schinella G, Gagliardino JJ, Francini F. Lipoic acid prevents liver metabolic changes induced by administration of a fructose-rich diet. Biochim Biophys Acta. 2013 Jan;1830(1):2226-32.

Han T, Bai J, Liu W, Hu Y.A systematic review and meta-analysis of α-lipoic acid in the treatment of diabetic peripheral neuropathy. Eur J Endocrinol. 2012 Oct;167(4):465-71.

Li CJ, Lv L, Li H, Yu DM.Cardiac fibrosis and dysfunction in experimental diabetic cardiomyopathy are ameliorated by alpha-lipoic acid. Cardiovasc Diabetol. 2012 Jun 19;11:73.

Wu H, Xu G, Liao Y, Ren H, Fan J, Sun Z, Zhang M.Supplementation with antioxidants attenuates transient worsening of retinopathy in diabetes caused by acute intensive insulin therapy. Graefes Arch Clin Exp Ophthalmol. 2012 Oct;250(10):1453-8.

Harding SV, Rideout TC, Jones PJ.Evidence for using alpha-lipoic acid in reducing lipoprotein and inflammatory related atherosclerotic risk. J Diet Suppl. 2012 Jun;9(2):116-27.

Porasuphatana S, Suddee S, Nartnampong A, Konsil J, Harnwong B, Santaweesuk A.Glycemic and oxidative status of patients with type 2 diabetes mellitus following oral administration of alpha-lipoic acid: a randomized double-blinded placebo-controlled study. Asia Pac J Clin Nutr. 2012;21(1):12-21.

Bertolotto F, Massone A.Combination of alpha lipoic acid and superoxide dismutase leads to physiological and symptomatic improvements in diabetic neuropathy. Drugs R D. 2012 Mar 1;12(1):29-34.

Golbidi S, Badran M, Laher I. Diabetes and alpha lipoic Acid. Front Pharmacol. 2011 Nov 17;2:69.

McIlduff CE, Rutkove SB.Critical appraisal of the use of alpha lipoic acid (thioctic acid) in the treatment of symptomatic diabetic polyneuropathy. Ther Clin Risk Manag. 2011;7:377-85.

Rahman ST, Merchant N, Haque T, Wahi J, Bhaheetharan S, Ferdinand KC, Khan BV.The impact of lipoic acid on endothelial function and proteinuria in quinapril-treated diabetic patients with stage I hypertension: results from the QUALITY study.J Cardiovasc Pharmacol Ther. 2012 Jun;17(2):139-45

Ansar H, Mazloom Z, Kazemi F, Hejazi N.Effect of alpha-lipoic acid on blood glucose, insulin resistance and glutathione peroxidase of type 2 diabetic patients.Saudi Med J. 2011 Jun;32(6):584-8.

Zhang Y, Han P, Wu N, He B, Lu Y, Li S, Liu Y, Zhao S, Liu L, Li Y.Amelioration of lipid abnormalities by α-lipoic acid through antioxidative and anti-inflammatory effects.Obesity (Silver Spring). 2011 Aug;19(8):1647-53

Heinisch BB, Francesconi M, Mittermayer F, Schaller G, Gouya G, Wolzt M, Pleiner J.Alpha-lipoic acid improves vascular endothelial function in patients with type 2 diabetes: a placebo-controlled randomized trial. Eur J Clin Invest. 2010 Feb;40(2):148-54.

Ghibu S, Richard C, Vergely C, Zeller M, Cottin Y, Rochette L. Antioxidant properties of an endogenous thiol: Alpha-lipoic acid, useful in the prevention of cardiovascular diseases.J Cardiovasc Pharmacol. 2009 Nov;54(5):391-8.

Henriksen EJ.Exercise training and the antioxidant alpha-lipoic acid in the treatment of insulin resistance and type 2 diabetes. Free Radic Biol Med. 2006 Jan 1;40(1):3-12.

Gymnema sylvestre

Pothuraju R, Sharma RK, Chagalamarri J, Jangra S, Kumar Kavadi P.A systematic review of Gymnema sylvestre in obesity and diabetes management.J Sci Food Agric. 2013 Oct 24. doi: 10.1002/jsfa.6458. [Epub ahead of print]

Kumar V, Bhandari U, Tripathi CD, Khanna G.Evaluation of antiobesity and cardioprotective effect of Gymnema sylvestre extract in murine model. Indian J Pharmacol. 2012 Sep-Oct;44(5):607-13.

Al-Romaiyan A, King AJ, Persaud SJ, Jones PM. A novel extract of Gymnema sylvestre improves glucose tolerance in vivo and stimulates insulin secretion and synthesis in vitro. Phytother Res. 2013 Jul;27(7):1006-11.

Khan V, Najmi AK, Akhtar M, Aqil M, Mujeeb M, Pillai KK.A pharmacological appraisal of medicinal plants with antidiabetic potential.J Pharm Bioallied Sci. 2012 Jan;4(1):27-42

Kang MH, Lee MS, Choi MK, Min KS, Shibamoto T.Hypoglycemic activity of Gymnema sylvestre extracts on oxidative stress and antioxidant status in diabetic rats. J Agric Food Chem. 2012 Mar 14;60(10):2517-24.

Prabhakar PK, Doble M.Mechanism of action of natural products used in the treatment of diabetes mellitus.Chin J Integr Med. 2011 Aug;17(8):563-74

Kumar SN, Mani UV, Mani I. An open label study on the supplementation of Gymnema sylvestre in type 2 diabetics. J Diet Suppl. 2010 Sep;7(3):273-82.

Ramkumar KM, Vijayakumar RS, Ponmanickam P, Velayuthaprabhu S, Archunan G, Rajaguru P.Antihyperlipidaemic effect of Gymnema montanum: a study on lipid profile and fatty acid composition in experimental diabetes.Basic Clin Pharmacol Toxicol. 2008 Dec;103(6):538-45

Biotin

Hemmati M, Babaei H, Abdolsalehei M.Survey of the effect of biotin on glycemic control and plasma lipid concentrations in type 1 diabetic patients in kermanshah in iran (2008-2009). Oman Med J. 2013 May;28(3):195-8.

Lazo de la Vega-Monroy ML, Larrieta E, German MS, Baez-Saldana A, Fernandez-Mejia C. Effects of biotin supplementation in the diet on insulin secretion, islet gene expression, glucose homeostasis and beta-cell proportion.J Nutr Biochem. 2013 Jan;24(1):169-77

Albarracin C, Fuqua B, Geohas J, Juturu V, Finch MR, Komorowski JR.Combination of chromium and biotin improves coronary risk factors in hypercholesterolemic type 2 diabetes mellitus: a placebo-controlled, double-blind randomized clinical trial.J Cardiometab Syndr. 2007 Spring;2(2):91-7

Albarracin CA, Fuqua BC, Evans JL, Goldfine IDChromium picolinate and biotin combination improves glucose metabolism in treated, uncontrolled overweight to obese patients with type 2 diabetes. Diabetes Metab Res Rev. 2008 Jan-Feb;24(1):41-51.

Geohas J, Daly A, Juturu V, Finch M, Komorowski JR.Chromium picolinate and biotin combination reduces atherogenic index of plasma in patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized clinical trial. Am J Med Sci. 2007 Mar;333(3):145-53.

McCarty MF. Exenatide and biotin in conjunction with a protein-sparing fast for normalization of beta cell function in type 2 diabetics.Med Hypotheses. 2007;69(4):928-32

Singer GM, Geohas J.The effect of chromium picolinate and biotin supplementation on glycemic control in poorly controlled patients with type 2 diabetes mellitus: a placebo-controlled, double-blinded, randomized trial.Diabetes Technol Ther. 2006 Dec;8(6):636-43.

McCarty MF.High-dose biotin, an inducer of glucokinase expression, may synergize with chromium picolinate to enable a definitive nutritional therapy for type II diabetes.Med Hypotheses. 1999 May;52(5):401-6.

Koutsikos D, Fourtounas C, Kapetanaki A, Agroyannis B, Tzanatos H, Rammos G, Kopelias I, Bosiolis B, Bovoleti O, Darema M, Sallum G.Oral glucose tolerance test after high-dose i.v. biotin administration in normoglucemic hemodialysis patients.Ren Fail. 1996 Jan;18(1):131-7.

Koutsikos D, Agroyannis B, Tzanatos-Exarchou H.Biotin for diabetic peripheral neuropathy.Biomed Pharmacother. 1990;44(10):511-4

Larrieta E, Velasco F, Vital P, López-Aceves T, Lazo-de-la-Vega-Monroy ML, Rojas A, Fernandez-Mejia C.Pharmacological concentrations of biotin reduce serum triglycerides and the expression of lipogenic genes.Eur J Pharmacol. 2010 Oct 10;644(1-3):263-8. doi: 10.1016/j.ejphar.2010.07.009. Epub 2010 Jul 23.

Cinnamon

Allen RW, Schwartzman E, Baker WL, Coleman CI, Phung OJ.Cinnamon use in type 2 diabetes: an updated systematic review and meta-analysis.Ann Fam Med. 2013 Sep-Oct;11(5):452-9

Akilen R, Pimlott Z, Tsiami A, Robinson N.Effect of short-term administration of cinnamon on blood pressure in patients with prediabetes and type 2 diabetes. Nutrition. 2013 Oct;29(10):1192-6.

Jiao L, Zhang X, Huang L, Gong H, Cheng B, Sun Y, Li Y, Liu Q, Zheng L, Huang K.Proanthocyanidins are the major anti-diabetic components of cinnamon water extract.Food Chem Toxicol. 2013 Jun;56:398-405

Cheng DM, Kuhn P, Poulev A, Rojo LE, Lila MA, Raskin I.In vivo and in vitro antidiabetic effects of aqueous cinnamon extract and cinnamon polyphenol-enhanced food matrix. Food Chem. 2012 Dec 15;135(4):2994-3002.

IVafa M, Mohammadi F, Shidfar F, Sormaghi MS, Heidari I, Golestan B, Amiri F. Effects of cinnamon consumption on glycemic status, lipid profile and body composition in type 2 diabetic patients.Int J Prev Med. 2012 Aug;3(8):531-6.

Rafehi H, Ververis K, Balcerczyk A, Ziemann M, Ooi J, Hu S, Kwa FA, Loveridge SJ, Georgiadis GT, El-Osta A, Karagiannis TC.Investigation of the biological properties of Cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis. Pathobiol Aging Age Relat Dis. 2012;2.

Lu T, Sheng H, Wu J, Cheng Y, Zhu J, Chen Y.Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes.Nutr Res. 2012 Jun;32(6):408-12

Akilen R, Tsiami A, Devendra D, Robinson N.Cinnamon in glycaemic control: Systematic review and meta analysis. Clin Nutr. 2012 Oct;31(5):609-15.

Hoehn AN, Stockert AL.The Effects of Cinnamomum Cassia on Blood Glucose Values are Greater than those of Dietary Changes Alone. Nutr Metab Insights. 2012 Dec 13;5:77-83.

Bandara T, Uluwaduge I, Jansz ER. Bioactivity of cinnamon with special emphasis on diabetes mellitus: a review. Int J Food Sci Nutr. 2012 May;63(3):380-6.

Gruenwald J, Freder J, Armbruester N.Cinnamon and health.Crit Rev Food Sci Nutr. 2010 Oct;50(9):822-34

Davis PA, Yokoyama W. Cinnamon intake lowers fasting blood glucose: meta-analysis.J Med Food. 2011 Sep;14(9):884-9

Akilen R, Tsiami A, Devendra D, Robinson N.Glycated haemoglobin and blood pressure-lowering effect of cinnamon in multi-ethnic Type 2 diabetic patients in the UK: a randomized, placebo-controlled, double-blind clinical trial.Diabet Med. 2010 Oct;27(10):1159-67

Qin B, Panickar KS, Anderson RA.Cinnamon: potential role in the prevention of insulin resistance, metabolic syndrome, and type 2 diabetes.J Diabetes Sci Technol. 2010 May 1;4(3):685-93.

Crawford P.Effectiveness of cinnamon for lowering hemoglobin A1C in patients with type 2 diabetes: a randomized, controlled trial.J Am Board Fam Med. 2009 Sep-Oct;22(5):507-12

Jitomir J, Willoughby DS.Cassia cinnamon for the attenuation of glucose intolerance and insulin resistance resulting from sleep loss. J Med Food. 2009 Jun;12(3):467-72.

Roussel AM, Hininger I, Benaraba R, Ziegenfuss TN, Anderson RA.Antioxidant effects of a cinnamon extract in people with impaired fasting glucose that are overweight or obese. J Am Coll Nutr. 2009 Feb;28(1):16-21.

Solomon TP, Blannin AK.Changes in glucose tolerance and insulin sensitivity following 2 weeks of daily cinnamon ingestion in healthy humans.Eur J Appl Physiol. 2009 Apr;105(6):969-76

Ziegenfuss TN, Hofheins JE, Mendel RW, Landis J, Anderson RA Effects of a water-soluble cinnamon extract on body composition and features of the metabolic syndrome in pre-diabetic men and women. J Int Soc Sports Nutr. 2006 Dec 28;3:45-53.

Peng X, Cheng KW, Ma J, Chen B, Ho CT, Lo C, Chen F, Wang M.Cinnamon bark proanthocyanidins as reactive carbonyl scavengers to prevent the formation of advanced glycation endproducts. J Agric Food Chem. 2008 Mar 26;56(6):1907-11.

Anderson RA.Chromium and polyphenols from cinnamon improve insulin sensitivity. Proc Nutr Soc. 2008 Feb;67(1):48-53.

Mang B, Wolters M, Schmitt B, Kelb K, Lichtinghagen R, Stichtenoth DO, Hahn A.Effects of a cinnamon extract on plasma glucose, HbA, and serum lipids in diabetes mellitus type 2.Eur J Clin Invest. 2006 May;36(5):340-4.

Khan A, Safdar M, Ali Khan MM, Khattak KN, Anderson RA. Cinnamon improves glucose and lipids of people with type 2 diabetes.Diabetes Care. 2003 Dec;26(12):3215-8.

Curcumin

Abdel Aziz MT, El-Asmar MF, Rezq AM, Mahfouz SM, Wassef MA, Fouad HH, Ahmed HH, Taha FM.The effect of a novel curcumin derivative on pancreatic islet regeneration in experimental type-1 diabetes in rats (long term study).Diabetol Metab Syndr. 2013 Nov 26;5(1):75

Son Y, Lee JH, Chung HT, Pae HO.Therapeutic roles of heme oxygenase-1 in metabolic diseases: curcumin and resveratrol analogues as possible inducers of heme oxygenase-1. Oxid Med Cell Longev. 2013;2013:639541.

Takikawa M, Kurimoto Y, Tsuda T.Curcumin stimulates glucagon-like peptide-1 secretion in GLUTag cells via Ca2+/calmodulin-dependent kinase II activation. Biochem Biophys Res Commun. 2013 May 31;435(2):165-70.

Soetikno V, Suzuki K, Veeraveedu PT, Arumugam S, Lakshmanan AP, Sone H, Watanabe KMolecular understanding of curcumin in diabetic nephropathy.Drug Discov Today. 2013 Aug;18(15-16):756-63

Oner-İyidoğan Y, Koçak H, Seyidhanoğlu M, Gürdöl F, Gülçubuk A, Yildirim F, Cevik A, Uysal M. Curcumin prevents liver fat accumulation and serum fetuin-A increase in rats fed a high-fat diet. J Physiol Biochem. 2013 Dec;69(4):677-86.

Steigerwalt R, Nebbioso M, Appendino G, Belcaro G, Ciammaichella G, Cornelli U, Luzzi R, Togni S, Dugall M, Cesarone MR, Ippolito E, Errichi BM, Ledda A, Hosoi M, Corsi M.Meriva®, a lecithinized curcumin delivery system, in diabetic microangiopathy and retinopathy. Panminerva Med. 2012 Dec;54(1 Suppl 4):11-6.

Shehzad A, Rehman G, Lee YS.Curcumin in inflammatory diseases. Biofactors. 2013 Jan-Feb;39(1):69-77.

Kapakos G, Youreva V, Srivastava AK.Cardiovascular protection by curcumin: molecular aspects.Indian J Biochem Biophys. 2012 Oct;49(5):306-15.

Yu W, Wu J, Cai F, Xiang J, Zha W, Fan D, Guo S, Ming Z, Liu C.Curcumin alleviates diabetic cardiomyopathy in experimental diabetic rats. PLoS One. 2012;7(12):e52013.

Sahebkar A.Why it is necessary to translate curcumin into clinical practice for the prevention and treatment of metabolic syndrome?Biofactors. 2013 Mar-Apr;39(2):197-208

Gupta SC, Patchva S, Aggarwal BB.Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013 Jan;15(1):195-218.

Meng B, Li J, Cao H.Antioxidant and antiinflammatory activities of curcumin on diabetes mellitus and its complications.Curr Pharm Des. 2013;19(11):2101-13.

Chuengsamarn S, Rattanamongkolgul S, Luechapudiporn R, Phisalaphong C, Jirawatnotai S.Curcumin extract for prevention of type 2 diabetes.Diabetes Care. 2012 Nov;35(11):2121-7

He HJ, Wang GY, Gao Y, Ling WH, Yu ZW, Jin TR.Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice. World J Diabetes. 2012 May 15;3(5):94-104.

Stefanska B.Curcumin ameliorates hepatic fibrosis in type 2 diabetes mellitus – insights into its mechanisms of action. Br J Pharmacol. 2012 Aug;166(8):2209-11.

Appendino G, Belcaro G, Cornelli U, Luzzi R, Togni S, Dugall M, Cesarone MR, Feragalli B, Ippolito E, Errichi BM, Pellegrini L, Ledda A, Ricci A, Bavera P, Hosoi M, Stuard S, Corsi M, Errichi S, Gizzi G.Potential role of curcumin phytosome (Meriva) in controlling the evolution of diabetic microangiopathy. A pilot study.Panminerva Med. 2011 Sep;53(3 Suppl 1):43-9

Gupta SC, Patchva S, Koh W, Aggarwal BB.Discovery of curcumin, a component of golden spice, and its miraculous biological activities. Clin Exp Pharmacol Physiol. 2012 Mar;39(3):283-99.

Khajehdehi P, Pakfetrat M, Javidnia K, Azad F, Malekmakan L, Nasab MH, Dehghanzadeh G.Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-βand interleukin-8 levels in patients with overt type 2 diabetic nephropathy: a randomized, double-blind and placebo-controlled study.Scand J Urol Nephrol. 2011 Nov;45(5):365-70. doi: 10.3109/00365599.2011.585622. Epub 2011 May 31.

Gupta SK, Kumar B, Nag TC, Agrawal SS, Agrawal R, Agrawal P, Saxena R, Srivastava S.Curcumin prevents experimental diabetic retinopathy in rats through its hypoglycemic, antioxidant, and anti-inflammatory mechanisms. J Ocul Pharmacol Ther. 2011 Apr;27(2):123-30.

Alappat L, Awad AB.Curcumin and obesity: evidence and mechanisms.Nutr Rev. 2010 Dec;68(12):729-38

Marczylo TH, Verschoyle RD, Cooke DN, Morazzoni P, Steward WP, Gescher AJ.Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine.Cancer Chemother Pharmacol. 2007 Jul;60(2):171-7

Cuomo J, Appendino G, Dern AS, Schneider E, McKinnon TP, Brown MJ, Togni S, Dixon BM.Comparative absorption of a standardized curcuminoid mixture and its lecithin formulation. J Nat Prod. 2011 Apr 25;74(4):664-9.

Appendino G, Belcaro G, Cornelli U, Luzzi R, Togni S, Dugall M, Cesarone MR, Feragalli B, Ippolito E, Errichi BM, Pellegrini L, Ledda A, Ricci A, Bavera P, Hosoi M, Stuard S, Corsi M, Errichi S, Gizzi G.Potential role of curcumin phytosome (Meriva) in controlling the evolution of diabetic microangiopathy. A pilot study.Panminerva Med. 2011 Sep;53(3 Suppl 1):43-9.

Resveratrol

Baker NA, English V, Sunkara M, Morris AJ, Pearson KJ, Cassis LA.Resveratrol protects against polychlorinated biphenyl-mediated impairment of glucose homeostasis in adipocytes.J Nutr Biochem. 2013 Dec;24(12):2168-74

Kumar A, Negi G, Sharma SS. Neuroprotection by resveratrol in diabetic neuropathy: concepts & mechanisms.Curr Med Chem. 2013;20(36):4640-5.

Kitada M, Koya D. SIRT1 in Type 2 Diabetes: Mechanisms and Therapeutic Potential. Diabetes Metab J. 2013 Oct;37(5):315-325.

Jimenez-Gomez Y, Mattison JA, Pearson KJ, Martin-Montalvo A, Palacios HH, Sossong AM, Ward TM, Younts CM, Lewis K, Allard JS, Longo DL, Belman JP, Malagon MM, Navas P, Sanghvi M, Moaddel R, Tilmont EM, Herbert RL, Morrell CH, Egan JM, Baur JA, Ferrucci L, Bogan JS, Bernier M, de Cabo R. Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet.Cell Metab. 2013 Oct 1;18(4):533-45

Movahed A, Nabipour I, Lieben Louis X, Thandapilly SJ, Yu L, Kalantarhormozi M, Rekabpour SJ, Netticadan T.Antihyperglycemic effects of short term resveratrol supplementation in type 2 diabetic patients. Evid Based Complement Alternat Med. 2013;2013:851267. doi: 10.1155/2013/851267. Epub 2013 Sep 1.

Dash S, Xiao C, Morgantini C, Szeto L, Lewis GF.High-dose resveratrol treatment for 2 weeks inhibits intestinal and hepatic lipoprotein production in overweight/obese men.Arterioscler Thromb Vasc Biol. 2013 Dec;33(12):2895-901

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Fiori JL, Shin YK, Kim W, Krzysik-Walker SM, González-Mariscal I, Carlson OD, Sanghvi M, Moaddel R, Farhang K, Gadkaree SK, Doyle ME, Pearson KJ, Mattison JA, de Cabo R, Egan JM.Resveratrol prevents β-cell dedifferentiation in nonhuman primates given a high-fat/high-sugar diet.Diabetes. 2013 Oct;62(10):3500-13

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